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Prof. Dr.
Volker Dötsch
Prof. Dr.
Michael Karas
Division V is a technology platform representing the arsenal of techniques available within FIRST and its associates and which is essential to address the specific needs of biomedical translational research. This division is a virtual integration of several core laboratories and technologies. Since a principal aim of FIRST is to cover all stages of target identification and drug development, i.e. from basic science research through to clinical trials, division V is an essential platform for all FIRST students. Over the last few years, Frankfurt University has established a critical mass of core facilities, including a proteomics center, functional genomics center, mass and NMR spectrometry units, medicinal chemistry and molecular modeling center, LC-MS/MS core unit for determination of drugs and their metabolites, an animal core facility, SNP screening unit for pharmacogenetics, a monoclonal antibody facility specialized on antibodies directed against proteins and small molecular weight compounds and a population pharmacokinetic/pharmacodynamic modeling unit. Clinical platforms include the Brain Imaging Center, a phase I unit and the Clinical Study Center Rhine-Main (kSRM). In addition, internationally acclaimed experts in drug formulation and in the structural characterization of biomolecules and their interaction with drugs by NMR and who belong to the Center of Biomolecular Magnetic Resonance Spectroscopy (BMRZ) will be contributing to the program. Furthermore, the Beilstein Endowed Chair for Chemical and Biological Informatics, which creates algorithms to identify potent ligands/inhibitors for receptors, enzymes and receptors as well as providing access to a great variety of data bases, offers a unique opportunity for PhD students to learn about state-of-the-art methods in computational chemistry being applied in lead compound identification and optimization. Not only will FIRST students have access to this technology platform, the respective experts will be actively involved in the FIRST teaching program.
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